Deaths of Despair: Negative Affect/Hyperkatifeia, Addiction and Co-Occurring Psychiatric Disorders, with George Koob

June 24, 2021 4:00 pm - 6:00 pm

Event Organizer



A mini-symposium hosted by

Center for Healing Opioid and Other Substance Use Disorders (CHOSEN)


GEORGE KOOB (bio), Director of the National Institute on Alcohol Abuse and Alcoholism

About the Event

Co-occurrence of substance and other psychiatric disorders is ubiquitous. Psychiatric disorders, including depression, Attention Deficit Hyperactivity Disorder (ADHD), Posttraumatic Stress Disorder (PTSD), anxiety disorders, and schizophrenia commonly co-occur with substance use disorders, including alcohol, opioids, stimulants, cannabis and nicotine. Comorbidity is associated with worse prognosis and the coordinated care of these patients remains a challenge. At this CHOSEN-hosted mini-symposium, Dr. George Koob, director of the National Institute on Alcohol Abuse and Alcoholism, will discuss the thesis and supporting pre-clinical and clinical evidence on negative affect or “hyperkatifeia” as a key driver of substance use disorders and potential mechanism underlying comorbidity. Before his presentation, several affiliates of CHOSEN will present on the latest clinical research on:

  • depression – Dr. Edward Nunes (bio)
  • ADHD – Dr. Frances Levin (bio)
  • PTSD – Dr. Denise Hien (bio)
  • suicide – Dr. Jeffrey Miller (bio)

The program concludes with a moderated discussion focused on potential mechanisms underlying addiction and comorbidity, and aimed at generating ideas for future clinical and pre-clinical research.

Attendees are encouraged to bring their data and ideas to share in the discussion.


The goal of CHOSEN is to foster cross-disciplinary collaboration across the entire University and reduce the negative health consequence caused by opioid and other substance use disorders. Integral to this mission is to promote research in social determinants of health associated with addiction and address health and racial inequities. Working across disciplines and departments, CHOSEN is committed to foster the next generation of addiction scientists. The senior leadership of CHOSEN consists of a partnership of the Columbia School of Social Work, the Division on Substance Use Disorders at CUIMC/NYSPI and the Irving Institute for Clinical and Translational Research. Over 45 faculty affiliates and 13 departments/schools of Columbia University and engaged in the Center’s activities. Read more here.